General Cell Lines and Cell Cultures
ATCC Salmonella enterica; subspecies enterica; serovar Typhimurium; Strain: SAP17-7699
Salmonella enterica subsp. enterica serovar Typhimurium strain SAP17-7699 was isolated from human feces in the United States. It has applications in food testing, enteric disease research, and zoonotic disease research.
ATCC HL-60; Promyelocytic Leukemia; Human (Homo sapiens)
HL-60 cells are promyeoloblasts isolated from the peripheral blood by leukopheresis from a 36-year-old,White, female with acute promyelocytic leukemia. This cell line can be used in immune disorder and immunology research.
Eurofins Discoverx cAMP Hunter CHO-K1 GPR81 Gi Cell Line, 2 vials. (95-0149C2)
The cAMP Hunter GPR81 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-lactate) based activation of GPR81 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GPR81, a naturally Gi/Go coupled GPCR. Upon activation of GPR81, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC SU-DHL-10; Large Cell Lymphoma; Human (Homo sapiens)
SU-DHL-10 is a B lymphocyte cell line that was isolated in 1978 from the lymph node of a 25-year-old, White male with large cell lymphoma. It has applications in immunology research.
ACROBiosystems CHO/Human PD-L1 Stable Cell Line (High Expression) Development Service
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Biochain Institute Inc Frozen Tissue Section - Dementia: Brain: Frontal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC NCI-H2023; Lung Carcinoma; Human (Homo sapiens)
NCI-H2023 [H2023] is a cell line that was isolated from the lungs of a 26-year-old, White, male patient with stage 3A non-small cell lung cancer: adenocarcinoma. This product has applications in cancer research.
Eurofins Discoverx Ready-to-Assay Ghrelin Receptor Frozen Cells, 2 Vials of Cells. (HTS187RTA)
The Ready-to-Assay Ghrelin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. ghrelin) based activation of GHSR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GHSR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GHSR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Genscript Corporation CHO-K1/ITGAE Stable Cell Line
Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human ITGAE is expressed widely on intraepithelial lymphocyte (IEL) T cells (both T cells and T cells) and on some peripheral regulatory T cells (Tregs) It has also been reported on lamina propria T cells A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes known as CD103 dendritic cells also expresses this marker
ATCC Aspergillus fumigatus; var. ellipticus NCMH 77
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
ATCC Klebsiella pneumoniae; Strain 1002565
Klebsiella pneumoniae subsp. pneumoniae strain 1002565 is a whole-genome sequenced bacterium that was isolated from a respiratory sample. This strain is resistant to ertapenem and imipenem and was confirmed by PCR to contain the blaNDM gene. This bacterial culture can be used in antimicrobial resistance research, drug development, infectious disease research, and respiratory disease research.
Genscript Corporation CHO-K1/ADRA2B/Gqi5 Stable Cell
Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter noradrenaline (norepinephrine) and the hormone and neurotransmitter adrenaline (epinephrine) Based on both pharmacological and molecular evidence they are divided into three major types - 1 2 and The 2 adrenoceptors include 3 subtypes - 2A 2B and 2C - each of which couples to G sub i/o /sub protein primarily br The 2B adrenoceptors (ADRA2B) is expressed in the kidney liver brain lung heart and skeletal muscle The development of 2B and 2C knock-out mice has shown that these two subtypes are not involved in the central hypotensive response to 2 agonists
Eurofins Discoverx PathHunter CHO-K1 cyno MRGPRX2 β-Arrestin Cell Line, 2 vials. (93-1134C2)
The PathHunter cyno MRGPRX2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAMP-20) based activation of cyno MRGPRX2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno MRGPRX2 and EA-tagged β-Arrestin-2. Activation of cyno MRGPRX2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Cynomolgus monkey version of the protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Array - 37 Different Kidney Tumors and 3 Corresponding Normal Controls, 5 slides/pk
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's human tumor frozen tissue arrays are designed for studying tumor tissue specific cellular localization of genes or proteins of interest in different human tissues. Same kind of tumors and corresponding normal tissues are mounted on positively charged slides.
Eurofins Discoverx PrecisION hASIC3 Recombinant Stable Cell Line, 2 vials. (CYL3055)
The PrecisION hASIC3 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying ASIC3 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses ASIC3 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.